Core Programs

Software and Research Tools

SIMLA Simulation Software Version 3.2

SIMLA_3.2 is a major upgrade to versions 2.3 and 3.0 that provides the ability to simulate two disease loci and two environmental covariates. Gene-gene and gene-environment interactions may also be simulated which jointly determine the disease risk of all pedigree members. Further enhancements include the simulation of X-linked markers and QTL effects with up to 12000 marker loci.

A description of the underlying simulation algorithm can be found in:
Schmidt MA, Hauser ER, Martin ER, Schmidt S. Extension of the SIMLA package for generating pedigrees with complex inheritance patterns: Environmental covariates, gene-gene and gene-environment interaction. Stat Appl Genet Mol Biol 4(1): article 15, 2005.

Please fill out the form below to download the SIMLA_3.2 program. This version is available for the Solaris, Linux and the Windows Operating Systems only. OSX is available by request only.

If you need SIMLA_3.2 for a different operating system, please contact simla@chg.duhs.duke.edu.

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