Core Programs

Software and Research Tools

SIMLA Simulation Software Version 2.3

SIMLA is a SIMulation program that generates data sets of families for use in Linkage and Association studies. It allows the user flexibility in specifying marker and disease placement, locus heterogeneity, disequilibrium between markers and between markers and disease loci. Output is in the form of a LINKAGE (Lathrop et al., Proc Natl Acad Sci USA 81, 1984) pedigree file and is easily utilized, either directly or with minimal reformatting, as input for various genetic analysis packages.

Version 2.3 introduces a fix that correctly generates covariate values for families when two or more disease loci are specified in the parameter file. An option to select only affecteds for calculating family-specific covariate means has also been added. The output has been enhanced for simulations with three or more disease loci.

Please fill out the form below to download the SIMLA Program. This version is available for the Solaris 7 (or higher) and Linux 2.4 Operating Systems.

If you need SIMLA for a different operating system, please contact simla@chg.duhs.duke.edu

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